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The development of epidemiological surveillance of infectious diseases and epidemiological research constitutes one of the aims of the IHU Méditerranée Infection; this involves the introduction of new tools for the detection of infections.
The microbiology laboratory of the IHU has set up the EPIMIC program; this provides a weekly monitoring both syndromic, based on the number of samples received at the laboratory, and targeted, based on the diagnosis of infectious agents. A significant increase is defined by a number of samples or diagnosis higher than an average based on historical data plus 2 standard deviations, and generates a visual alert (in red) (Colson et al., 2012a). The analysis of historical data (including graphs) also allows highlighting seasonalities. EPIMIC monitors notably critical pathogens in terms of mortality, involved in nosocomial infections and antibiotic resistance. EPIMIC has allowed alerting when abnormal elements occured, such as seasonality of Klebsiella pneumoniae bacteremia (Anderson et al., 2009), an increase of tonsillitis due to Streptococcus pyogenes (Parola et al., 2011), an increase of imipenem-resistant Acinetobacter baumanii infections (Kempf et al., 2012), an increase of cases of hepatitis E in early 2011 (Colson et al., 2012b).
The EPIMIC programme currently monitors almost 400 parameters; its historical data include more than 11 million events, with a follow-up average of approximately 5 years. EPIMIC operates on Microsoft Excel.
Anderson DJ, Richet H, Chen LF, Spelman DW, Hung YJ, Huang AT, Sexton DJ, Raoult D. Seasonal variation in Klebsiella pneumoniae bloodstream infection on 4 continents. J Infect Dis 2008;197(5):752-6.
Colson P, Richet H, Rolain JM, Parola P, Charrel R, Raoult D. EPIMIC: a simple home-made computer program for EPIdemiological bio- surveillance and alert based on MICrobiologic data. Clin Microbiol Infect 2012a;18(s3):74/O469.
Colson P, Romanet P, Moal V, Borentain P, Purgus R, Benezech A, Motte A, Gérolami R. Autochthonous infections with hepatitis E virus genotype 4 in France as a possible effect of globalization of zoonosis. Emerg Infect Dis 2012b;18(8):1361-4.
Kempf M, Rolain JM, Azza S, Diene S, Joly-Guillou ML, Dubourg G, Colson P, Papazian L, Richet H, Fournier PE, Raoult D. Investigation of Acinetobacter baumannii resistance to carbapenems in the south of France: a transition from an epidemic to an endemic situation. APMIS, in press.
Parola P, Colson P, Dubourg G, Million M, Charrel R, Minodier P, Raoult D. Letter to the editor. Group A streptococcal infections during the seasonal influenza outbreak 2010/11 in South East England. Euro Surveill 2011;16(11).